Mexidol is an original domestic new-type drug. Its mechanism of action is characterized by antioxidant and cerebroprotective properties.
Mexidol is an inhibitor of free-radical processes, membrane protectors, have anti, stress-protective, neuroprotective, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accident, alcohol intoxication and antipsychotics / neuroleptics /).
The mechanism of action of the drug Mexidol due to its antioxidant, anti-hypoxic and membrane action. The drug inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the ratio of lipid-protein, reduces the viscosity of the membrane increases its fluidity. Mexidol modulates the activity of membrane enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase) receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, it helps to preserve the structural and functional organization of biological membranes, transport of neurotransmitters and improve synaptic transmission. Meksidol content increases brain dopamine. It is a compensatory increase in the activation of aerobic glycolysis and decreased inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with increasing the content of ATP and creatine phosphate, activation energosinteziruyuschih functions of mitochondria, stabilizing cell membranes.
The drug improves metabolism and blood flow to the brain, improves microcirculation and blood rheology, reduces platelet aggregation. It stabilizes the membrane structure of blood cells (erythrocytes and platelets) for hemolysis. It has hypolipidemic effect, reduces total cholesterol and LDL.
Anti-stress effect is the normalization of post-stress behavior, somatic-vegetative disorders, recovery cycles "sleep-wake" disturbed learning and memory processes, and reducing the degenerative morphological changes in different brain structures.
Mexidol has a strong detoxifying effect in withdrawal syndrome. Eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral, autonomic functions, and is able to remove the cognitive impairment caused by prolonged use of ethanol and its abolition. Influenced Mexidol enhanced tranquilizing effect, antipsychotic, antidepressant, hypnotic and anticonvulsant agents, allowing them to reduce the dose and reduce side effects.
Mexidol improves the functional state of the ischemic myocardium. In the context of coronary insufficiency increases collateral blood flow to ischemic myocardium, helps to preserve and maintain the integrity of cardiomyocytes their functional activity. Effectively restores myocardial contractility with reversible cardiac dysfunction.
Absorption and distribution
Quickly absorbed by ingestion. Cmax at doses of 400-500 mg 3.5-4.0 mg / ml.
Quickly spread to organs and tissues. The average retention time of the drug in the body by ingestion - 4.9-5.2 hours.
It is metabolized in the liver by glyukuronkonyugirovaniya. Identified metabolites 5: 3-hydroxypyridine phosphate - formed in the liver and with the participation of ALP splits into phosphoric acid and 3-oxy-pyridin; 2nd metabolite - a pharmacologically active and is formed in large quantities and is found in the urine 1-2 hours after administration; 3rd - displayed in large amounts in the urine; 4 th and 5 th - glyukuronkonyugaty.
T1 / 2 at intake -. 2-2.6 hours quickly excreted in the urine mainly in the form of metabolites, and in small quantities - unchanged. The most extensively excreted within the first 4 hours after ingestion. Performance in the urine excretion of unchanged drug and metabolites have individual variability.
Due to insufficient knowledge of the drug:
Inside of 125-250 mg 3 times / day; the maximum daily dose - 800 mg (6 tab.). Duration of treatment - 2-6 weeks; for the relief of alcohol withdrawal - 5-7 days. Treatment stopped gradually, reducing the dose for 2-3 days.
The initial dose - 125-250 mg (1-2. Table) 1-2 times / day with a gradual increase until the therapeutic effect; the maximum daily dose - 800 mg (6 tab.).
Duration of therapy in patients with coronary heart disease is at least 1.5-2 months. Repeated courses (on doctor's advice) is preferably carried out in the spring and autumn periods.
In case of overdose may develop drowsiness.
In a joint application Mexidol enhances the action of benzodiazepines, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants.
Mexidol reduces the toxic effects of ethanol.
Pregnancy and lactation
Mexidol contraindicated during pregnancy and lactation (breastfeeding) due to insufficient knowledge of the drug.
From the digestive system: possible emergence of individual adverse reactions or dyspeptic dyspeptic character.
Other: allergic reactions.
Terms and Conditions of storage
The drug should be stored out of reach of children, dry, dark place at a temperature no higher than 25 ° C. Shelf life - 3 years. Do not use after the expiration date printed on the packaging.
Mexidol can be combined with all drugs used for the treatment of systemic diseases.
Use in Pediatrics
Mexidol not prescribed to children due to insufficient knowledge of the drug.
Effects on ability to drive vehicles and management mechanisms
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.